... inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg mice
... inhibitory peptide on interleukin-1β-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts, and its antiarthritic activity in hTNFtg ...
To address the question of whether osteoclasts play a pivotal role in this process, transgenic mice that express human TNF (hTNFtg) and that develop a severe and ...
Complete absence of osteoclasts in c-fos –/– hTNFtg mice and strong correlation between the number of osteoclasts and the size of erosions in hTNFtg mice.
It is notable that transgenic mice that express human TNF-α (hTNFtg mice) spontaneously develop destructive arthritis . Interestingly, the anti-TNF-α antibody has been ...
hnRNP-A2 is overexpressed in the joints of hTNFtg mice. Investigations previously performed in human synovial tissue had revealed hnRNP-A2 to be highly overexpressed in ...
However, in RA and in hTNFtg mice loss of proteoglycan in articular cartilage can also be found in the joint space, which is not directly attached by ...