The pooled half-life for plasma-derived FL-FVIII (13.7 h; CI, 12.8−14.6 h) was closely similar to that for recombinant FL-FVIII (14.3 h; CI, 13.3−15.4 h).
There was no significant difference in coagulation factor usage (BDD rFVIII median 4803 IU kg −1 year −1, range 659–11 304; FL FVIII median 5349, range 1691–10 146 ...
The pooled cumulative weekly prophylactic dose of BDD-rFVIII (81.3 ±13.8 IU/ kg)/week ) was greater by 36% (P ¼0.11) than that of FL-FVIII (60.0 ±5.9 IU/ kg)/week .
Rabbit PK study of PEGylated wildtype full-length (“fl”) FVIII compared to unmodified fl FVIII. FIG. 21. Hemophilic mouse PK study of PEGylated PEG6 compared to PEG6 ...